Association of Parental Age and the Type of Down Syndrome on the Territory of Bosnia and Herzegovina

Mia Sotonica, Mirela Mackic-Djurovic, Sabaheta Hasic, Emina Kiseljakovic, Radivoj Jadric, and Slavka Ibrulj

Abstract
Background: Advanced paternal and/or maternal age is a classic risk factor for Down syndrome. The aim of the study was to investigate the frequency of Down syndrome types in children and its association with maternal and paternal age in Bosnia and Herzegovina. Subjects and Methods: The cross sectional, observational study included 127 children, 49 girls and 78 boys, aged 1-180 months suspected to have Down syndrome, admitted to the Centre for Genetics, Faculty of Medicine University of Sarajevo, for cytogenetic analysis and differential diagnosis of Down syndrome during the period from January 2010 to May 2015. Standard method of 72 hours cultivation of peripheral blood lymphocytes has been applied. The accepted level of statistical significance was p<0.05. Study Results: The most common type of Down syndrome was standard trisomy (86.6%), comparing to translocation and mosaicism (7.1%; 6.3%, respectively). The highest frequency of Down syndrome cases was in mother and father's group from 30-39 years old (57; 57 children, respectively) compared to mother and father's groups with younger than 30 (44; 29, respectively) and 40 and older (26; 41, respectively). The significant difference was found in maternal age between translocation and mosaicism groups (p=0.036). Difference between parental years and type of Down syndrome was significant when Standard trisomy 21 and translocation (p=0.045), as well as mosaicism and translocation (p=0.036), were compared. [Med Arh 2016; 70(2.000): 88-91] Keywords: advanced age, trisomy 21, translocation, mosaicism

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By |2017-01-06T12:43:00+00:00January 6th, 2017|2, 70|Comments Off on Association of Parental Age and the Type of Down Syndrome on the Territory of Bosnia and Herzegovina