Cytogenetic Abnormalities Found in Patients with Reproductive Problems

Mirela Mackic-Djurovic, Sabaheta Hasic, Emina Kiseljakovic, Dunja Rukavina, Slavka Ibrulj

Introduction: One of the important causes of male infertility is aberration at the chromosomes. Aim: The main purpose of this study was to determine the frequency and types of chromosomal aberration in infertile/sterile men whose samples were analyzed in the Center for Cytogenetics of Faculty of Medicine University of Sarajevo in the last four years. Methods: A total of 353 infertile/sterile men, between the ages of 22-55 years, referred for cytogenetic analysis to the Center for Genetics of Faculty of Medicine during the period 2013-2016. Karyotyping was performed on peripheral blood lymphocytes by using the Giemsa trypsin banding (GTG) technique. Results: The structural and numerical chromosomal aberration in infertility/ sterility of men found with the incidence of 6% (20/353). Out of the 20 patients with abnormal cytogenetic diagnosis, structural chromosome abnormalities were observed in 17 (85%) patients and 3 (15%) with numerical aberrations. The type of aberrations mostly found were Robertsonian and reciprocal translocations (35%, 35%, respectively). Conclusions: The incidence of chromosomal abnormalities in infertile/sterile males suggests that the cytogenetics analysis is an important in male infertility, especially if it will be used for the purpose of assisted reproduction techniques.
[Med Arch 2017; 71(6.000): 396-399]

Keywords: Cytogenetic analysis, structural and numerical chromosomal aberration, infertility

>>Full text PDF        >>Abstract       >>[cite source=”doi”]10.5455/medarh.2017.71.396-399[/cite]

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